Direct selective oxygen-assisted acylation of amines driven by metallic silver surfaces: dimethylamine with formaldehyde
Publication information:
Zhou L, Freyschlag C, Xu B, Friend C, Madix R. Direct selective oxygen-assisted acylation of amines driven by metallic silver surfaces: dimethylamine with formaldehyde. Chemical Communications. 2010;46:704–706.
Abstract
Facile, direct acylation of dimethylamine with formaldehyde to N, N-dimethylformamide proceeds with a selectivity approaching 100% at low oxygen concentrations on metallic silver surfaces; the reaction proceeds via nucleophilic attack of adsorbed dimethylamide ...